The club was founded on 28 September 1893 as Foot-Ball Club do Porto by António Nicolau de Almeida, a local port wine merchant and avid sportsman, who became fascinated with football during his trips to England. Porto played its first matches with other Portuguese clubs, including one against Lisbon's Foot-Ball Club Lisbonense on 2 March 1894. This match had the patronage of King Carlos I and Queen Amélie of Orléans, who traveled to Porto to witness the event and present a trophy to the winners.
Almeida's enthusiasm and involvement with the club waned due to family pressure, and by the turn of the century, Porto had entered a period of inactivity. In 1906, José Monteiro da Costa returned to Porto after finishing his studies in England. Like Almeida, thirteen years before, he was also captivated by the English game, and together with some associates, decided to reintroduce the practice of football in the city, outside of the British circles. On 2 August 1906, Porto was revived and Monteiro da Costa appointed its president. Although football was the driving force, the club also promoted other sports, including gymnastics, weightlifting and wrestling, athletics and swimming.Shortly after, Porto rented its first ground and recruited a French coach named Adolphe Cassaigne, who would stay in the club until 1925.
On 15 December 1907, Porto played its first match against a foreign team, hosting Spain's Real Fortuna. In the following month, Porto returned the visit and played its first match abroad. Four years later, the club won the inaugural staging of the Taça José Monteiro da Costa, securing its first-ever official title. In 1912, Porto joined efforts with Leixões to establish the Porto Football Association, which began organising the regional championship in the following year. Porto finished the first season as runners-up, behind local rivals Boavista, but in the following season the club won its first championship. By the end of the 1920–21 season, Porto had been regional champions six times in seven years, and outright winners of the Taça José Monteiro da Costa, after claiming a third consecutive victory in 1916
| Adrian|| Oliver|| Andres|
| Helton|| Kadu|| Maicon|
| Kelvin|| Ricardo|| Vincent Aboubakar|
| Mikel Ndubisi Agu|| Jose Angel|| Willy Boly|
| Yacine Brahimi|| José Campaña|| Iker Casillas|
| Fabiano Freitas|| Jorge Fucile|| Victor Garcia|
| Lucho Gonzalez|| Hector Herrera|| Gianelli Imbula|
| Joris Kayembe|| Miguel Layun|| Ivan Marcano|
| Daniel Opare|| Maxi Pereira|| Ricardo Pereira|
| Ricardo Quaresma|| Juan Quintero|| Diego Reyes|
| Alex Sandro Lobo Silv|| Joao Teixeira|| Silvestre Varela|