Manuel De Jesus Rodríguez (born August 6, 1996) is a Mexican professional baseball pitcher for the Chicago Cubs of Major League Baseball (MLB).
Rodríguez was added to the Cubs 40-man roster after the 2019 season. He opened the 2021 season with the Tennessee Smokies and the Iowa Cubs. In June 2021, Rodríguez was selected to play in the All-Star Futures Game.
On July 30, 2021, Chicago promoted him to the major leagues for the first time. He made his MLB debut that night, throwing a scoreless inning with two strikeouts in relief.
In 2021 he was 3-3 with a 6.11 ERA with the major league team. In 20 games he pitched 17.2 innings, in which he gave up 18 runs, 12 earned.