|26 Sep 21||Atlético Bucaramanga ||-|| América de|
|03 Oct 21||América de ||-|| Atlético Huila|
|10 Oct 21||Millonarios F.C. ||-|| América de|
|17 Oct 21||América de ||-|| Deportivo Cali|
|24 Oct 21||América de ||-|| Atlético Nacional|
|18 Sep 21||América de|| ||2 - 3|| ||Jaguares de|
|12 Sep 21||Deportivo Cali|| ||0 - 1|| ||América de|
|04 Sep 21||América de|| ||0 - 1|| ||Deportes Quindío|
|30 Aug 21||Independiente Santa|| ||1 - 1|| ||América de|
|21 Aug 21||América de|| ||0 - 0|| ||Patriotas Boyacá|
América de Cali S. A., best known as América de Cali or América, is a Colombian football team based in Cali and playing in the Categoría Primera A. They play their home games at the Olímpico Pascual Guerrero stadium. The club is regarded by FIFA and IFFHS as the strongest football team in Colombia and the ninth strongest in South America during the 20th century. IFFHS also once ranked América de Cali as the second best club side in the world, behind only Italian champions Juventus.
The club is one of the oldest in Colombia; they were founded in 1927, and trace their origins to the América Football Club, which was founded in 1918. They are also one of the most successful Colombian clubs at both the domestic and international levels, winning fourteen national titles and reaching the Copa Libertadores finals four times (including three straight from 1985 to 1987). Although they have never won the Copa Libertadores, they have won two international tournaments, the 1999 Copa Merconorte and the 1975 Copa Simón Bolívar.
| || || |