|26 Sep 21||Borgosesia Calcio  ||-|| Novara|
|10 Oct 21||Novara  ||-|| A.C. Bra|
|17 Oct 21||SC Ligorna  ||-|| Novara|
|31 Oct 21||Novara  ||-|| F.C. Vado|
|07 Nov 21||S.S.D. Sanremese  ||-|| Novara|
|02 May 21||Novara|| ||0 - 5|| ||Como|
|25 Apr 21||Olbia|| ||3 - 3|| ||Novara|
|18 Apr 21||Novara|| ||3 - 2|| ||Pistoiese|
|11 Apr 21||Pro Patria|| ||1 - 3|| ||Novara|
|03 Apr 21||Novara|| ||0 - 0|| ||Pergolettese|
In December 1908 the F.A.S. (Football Association Studenti) was created by eight students of Liceo Carlo Alberto, aged between 15–16 years; among them an engineer, Gianni Canestrini, and a lawyer, Piero Zorini. In Novara in those days, there were other small clubs like Voluntas, Pro Scalon, Ginnastica e Scherma, Forza & Speranza, Collegio Gallarini and many other student bodies. The best players from these teams came together to form Novara Calcio, and made their debut in the Italian league on 3 November 1912.
The first match was played against a team already then established as Torino, who won 2–1, with the first Novara goal scored by Mario Menendez.
In the years between World War I and World War II, Novara merged with Pro Vercelli, Alessandria and Casale to make the so-called "quadrilatero piemontese" (Piedmont Quadrilateral). Novara's highest finish came in 1952 when they finished in eighth place in Serie A.
During these years of staying in the top flight, Novara had Silvio Piola to thank. His many goals (which at the end of his career was over 300), made a huge contribution to the cause of Novara. Following his death in 1996, the stadium at which Novara play was dedicated in his name.
In 1956 came relegation to Serie B, and another five years afterwards, they slipped down to Serie C due to a fraudulent complaint by a Sambenedettese player.
A few successful seasons in Serie B followed, but then Novara stumbled again in 1977 with relegation to Serie C and worse in 1981 to Serie C2. In the 1995–96 season, Novara were back in Serie C1, but this joy was short-lived as the following year, the biancoazzurri again had to deal with relegation.
Years were spent in the shadows of Italian football until more recently when the league was won in the 2002–03 season.