Simon Pouplin (born 28 May 1985 in Cholet, Maine-et-Loire) is a former French football player.
In 2005, Pouplin signed his first professional contract with Stade Rennais, signing up with the Breton club for three years. He made his debut in the 2003–04 French Ligue 1 season. He played for German Bundesliga side SC Freiburg from the 2007–08 season until the 2010–11 season. He was on trial with Évian TG from Ligue 1 on July 2011 but was not signed due to injury.
After spending one year without a team, Pouplin signed a three-year contract with Ligue 1 outfit FC Sochaux-Montbéliard in July 2012.
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