17 Sep 21 | r08 | Cercle Brugg | 1 - 2 | Eupen |
18 Sep 21 | r08 | KV Oostende | 3 - 1 | Beerschot VA |
18 Sep 21 | r08 | St. Gilloise | 2 - 1 | Waregem |
18 Sep 21 | r08 | Mechelen | 2 - 0 | Oud-Heverlee |
18 Sep 21 | r08 | Charleroi | 0 - 1 | Club Brugge |
19 Sep 21 | r08 | St.Truiden | 1 - 2 | Genk |
19 Sep 21 | r08 | Antwerp | 2 - 1 | RFC Seraing |
19 Sep 21 | r08 | Standard | 0 - 1 | Anderlecht |
19 Sep 21 | r08 | Kortrijk | 1 - 0 | Gent |