26 Nov 21 | r16 | Mariupol | 0 - 1 | FC Lviv |
27 Nov 21 | r16 | Mynai | 0 - 2 | Dynamo Kiev |
27 Nov 21 | r16 | Chornomorets | 0 - 1 | Desna |
27 Nov 21 | r16 | SC Dnipro-1 | 5 - 1 | Vorskla |
28 Nov 21 | r16 | Inhulets | 0 - 1 | Shakhtar Don |
28 Nov 21 | r16 | Rukh Lviv | 2 - 0 | FC Metalist |
28 Nov 21 | r16 | FC Kolos Kov | 1 - 0 | Veres Rivne |
29 Nov 21 | r16 | FC Olexandri | 0 - 1 | Zorya |