13 May 22 | r34 | FC Porto B | 2 - 3 | Benfica B |
13 May 22 | r34 | Academico Vi | 1 - 2 | Penafiel |
14 May 22 | r34 | Associação | 0 - 0 | SC Farense |
14 May 22 | r34 | Vilafranquen | 2 - 4 | Trofense |
15 May 22 | r34 | Rio Ave | 3 - 0 | Chaves |
15 May 22 | r34 | Leixoes | 1 - 5 | Casa Pia |
15 May 22 | r34 | Feirense | 4 - 1 | CD Nacional |
15 May 22 | r34 | Varzim | 2 - 0 | Mafra |
15 May 22 | r34 | Estrela Amad | 0 - 1 | Covilha |