13 Feb 22 | r01 | TP Mazembe | 1 - 0 | AS Otohô |
13 Feb 22 | r01 | Coton Sport | 0 - 0 | Al-Masry |
13 Feb 22 | r01 | Simba SC | 3 - 1 | ASEC Mimosas |
13 Feb 22 | r01 | Pyramids FC | 2 - 1 | Al Ahli Trip |
13 Feb 22 | r01 | Orlando Pira | 2 - 0 | JS Saoura |
13 Feb 22 | r01 | CS Sfaxien | 1 - 0 | Zanaco |
13 Feb 22 | r01 | RS Berkane | 5 - 3 | US GN |
06 Mar 22 | r01 | Royal Leopar | 1 - 2 | Al-Ittihad T |