27 Feb 22 | r03 | TP Mazembe | 1 - 0 | Coton Sport |
27 Feb 22 | r03 | Pyramids FC | 1 - 0 | CS Sfaxien |
27 Feb 22 | r03 | Al-Ittihad T | 1 - 1 | JS Saoura |
27 Feb 22 | r03 | AS Otohô | 1 - 0 | Al-Masry |
27 Feb 22 | r03 | US GN | 2 - 0 | ASEC Mimosas |
27 Feb 22 | r03 | Al Ahli Trip | 2 - 0 | Zanaco |
27 Feb 22 | r03 | RS Berkane | 2 - 0 | Simba SC |
27 Feb 22 | r03 | Royal Leopar | 2 - 6 | Orlando Pira |