20 Mar 22 | r05 | Zanaco | 1 - 0 | CS Sfaxien |
20 Mar 22 | r05 | Al-Masry | 2 - 0 | Coton Sport |
20 Mar 22 | r05 | AS Otohô | 2 - 2 | TP Mazembe |
20 Mar 22 | r05 | US GN | 2 - 2 | RS Berkane |
20 Mar 22 | r05 | ASEC Mimosas | 3 - 0 | Simba SC |
20 Mar 22 | r05 | Al-Ittihad T | 3 - 2 | Royal Leopar |
20 Mar 22 | r05 | Al Ahli Trip | 1 - 0 | Pyramids FC |
20 Mar 22 | r05 | JS Saoura | 0 - 2 | Orlando Pira |