10 Dec 21 | r16 | Badajoz | 2 - 1 | Tudelano |
11 Dec 21 | r16 | Real Unión | 0 - 3 | Racing Club |
11 Dec 21 | r16 | SS Reyes | 3 - 1 | SD Logroñé |
11 Dec 21 | r16 | Santander | 3 - 2 | Rayo Majadah |
11 Dec 21 | r16 | Zamora | 2 - 2 | Leonesa |
12 Dec 21 | r16 | Celta Vigo B | 2 - 0 | Talavera |
12 Dec 21 | r16 | Calahorra | 1 - 1 | Unionistas d |
12 Dec 21 | r16 | Inter de Mad | 3 - 0 | Athletic Bil |
12 Dec 21 | r16 | La Coruna | 3 - 0 | Valladolid P |
12 Dec 21 | r16 | UD Logroñé | 1 - 3 | Extremadura |