|30 Oct 21||OFI ||-|| Atromitos|
|06 Nov 21||NFC Volos ||-|| OFI|
|20 Nov 21||OFI ||-|| Ionikos|
|27 Nov 21||OFI ||-|| Olympiakos|
|04 Dec 21||Apollon Smirnis ||-|| OFI|
|24 Oct 21||OFI|| ||0 - 0|| ||Lamia|
|23 Oct 21||Panathinaikos|| ||P - P|| ||OFI|
|17 Oct 21||Panetolikos|| ||1 - 2|| ||OFI|
|16 Oct 21||OFI|| ||P - P|| ||Lamia|
|03 Oct 21||OFI|| ||1 - 3|| ||PAOK|
OFI Football Club (Greek: ΠΑΕ Όμιλος Φιλάθλων Ηρακλείου 1925, Club of Fans of Heraklion 1925), is a Greek association football club based in Heraklion, on the island of Crete. It is a part of the OFI multi sports club. Outside Greece, the club is generally known as OFI Crete, however, the name Crete is not actually part of the club's official title. The team competes in the Super League, the top division of the Greek football league system, and hosts home games at the Theodoros Vardinogiannis Stadium.
OFI is the Cretan club with the most continuous appearances in the Greek first division. It has won one Greek Cup (1986–87) and one Balkans Cup, while they have competed seven times in UEFA competitions.