|17 Oct 21||América de ||-|| Deportivo Cali|
|24 Oct 21||Rionegro Águilas ||-|| Deportivo Cali|
|31 Oct 21||Deportivo Cali ||-|| Patriotas Boyacá|
|07 Nov 21||Atlético Huila ||-|| Deportivo Cali|
|14 Nov 21||Deportivo Cali ||-|| Deportes Quindío|
|16 Oct 21||América de|| ||1 - 1|| ||Deportivo Cali|
|09 Oct 21||Deportivo Cali|| ||2 - 2|| ||La Equidad|
|02 Oct 21||Envigado F.C.|| ||1 - 2|| ||Deportivo Cali|
|24 Sep 21||Deportivo Cali|| ||2 - 1|| ||Deportivo Pereira|
|19 Sep 21||Deportes Tolima|| ||1 - 1|| ||Deportivo Cali|
Asociación Deportivo Cali, best known as Deportivo Cali, is a Colombian sports club based in Cali, most notable for its football team, which currently competes in the Categoría Primera A.
Deportivo Cali is one of the most successful football teams in Colombia, having won nine domestic league championships, one Copa Colombia and one Superliga Colombiana, for eleven titles. Their stadium, Estadio Deportivo Cali, with an original capacity of 61,890, is the largest football stadium in Colombia and was officially inaugurated on 19 November 2008. In 2010 its capacity was reduced to 55,000 people due to renovations. Deportivo Cali's old home stadium was Estadio Olímpico Pascual Guerrero, with a capacity of 43,130. Deportivo Cali is the only Colombian football club that owns its own stadium. It was also the first Colombian team to reach the final of Copa Libertadores in 1978. In 2016, Forbes listed Deportivo Cali as the 36th most valuable team of America.
| || || |