|17 Oct 21||Blooming|| ||3 - 1|| ||Real Santa|
|27 Sep 21||Real Santa|| ||3 - 0|| ||Club Deportivo|
|21 Sep 21||Real Potosi|| ||3 - 0|| ||Real Santa|
|18 Sep 21||Real Santa|| ||2 - 1|| ||Royal Pari|
|14 Sep 21||Always Ready|| ||4 - 0|| ||Real Santa|
Club Real Santa Cruz is a football club from Santa Cruz, Bolivia currently playing in the top-flight División Profesional after winning promotion in 2019. The club last played in the first division in 2004; they also played the Copa Bolivia in 2001, when they became runners-up. They play their home games at the Estadio Juan Carlos Duran.