|18 May 21||Independiente|| ||-||Bahia|
|18 May 21||Club River Plat|| ||-||Peñarol|
|19 May 21||Wilstermann|| ||-||Arsenal Sarandi|
|19 May 21||Atletico GO|| ||-||Club Libertad|
|19 May 21||Emelec|| ||-||Deportes Tolima|
|19 May 21||Talleres de Cor|| ||-||Bragantino|
|20 May 21||Rosario Central|| ||-||Huachipato|
|20 May 21||12 de Octubre|| ||-||San Lorenzo|
|20 May 21||Ceara|| ||-||Bolivar|
|20 May 21||Atletico PR|| ||-||FBC Melgar|
|14 May 21||SD Aucas ||2 - 1|| ||FBC Melgar|
|14 May 21||Club River Plat ||2 - 1|| ||Sport Huancayo|
|14 May 21||Peñarol ||4 - 0|| ||Corinthians|
|14 May 21||Club Libertad ||1 - 0|| ||Newells Old Boy|
|13 May 21||San Lorenzo ||1 - 2|| ||Rosario Central|
|13 May 21||Club Deportivo  ||0 - 1|| ||Bahia|
|13 May 21||Bolivar ||2 - 2|| ||Wilstermann|
|13 May 21||Atletico GO ||0 - 0|| ||Palestino|
|13 May 21||Aragua F.C. ||1 - 2|| ||La Equidad|
|13 May 21||Gremio ||3 - 1|| ||Lanus|
The CONMEBOL Sudamericana, named as Copa Sudamericana is an annual international club football competition organized by CONMEBOL since 2002. It is the second-most prestigious club competition in South American football. CONCACAF clubs were invited between 2004 and 2008. The CONMEBOL Sudamericana began in 2002, replacing the separate competitions Copa Merconorte and Copa Mercosur (that had replaced Copa CONMEBOL) by a single competition. Since its introduction, the competition has been a pure elimination tournament with the number of rounds and teams varying from year to year.
The CONMEBOL Sudamericana is considered a merger of defunct tournaments such as the Copa CONMEBOL, Copa Mercosur and Copa Merconorte. The winner of the Copa Sudamericana becomes eligible to play in the Recopa Sudamericana. They gain entry onto the next edition of the Copa Libertadores, South America's premier club competition, and also contest the J.League Cup / Copa Sudamericana Championship.
The reigning champion of the competition is Ecuadorian club Independiente del Valle, who defeated Argentine club Colón in the most recent final.
Argentine clubs have accumulated the most victories with eight while containing the largest number of different winning teams, with a total of six clubs having won the title. The cup has been won by 15 different clubs. Argentine clubs Boca Juniors and Independiente are the most successful clubs in the cup's history, having won the tournament twice, with Boca Juniors being the only one to achieve it back-to-back, in 2004 and 2005.
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