|23 Jul 21||Peñarol ||0 - 1|| ||Nacional Montev|
|23 Jul 21||Rosario Central ||1 - 0|| ||Deportivo Tách|
|22 Jul 21||Bragantino ||1 - 1|| ||Independiente d|
|22 Jul 21||Independiente ||1 - 1|| ||Santos FC|
|22 Jul 21||Club Libertad ||0 - 1|| ||Atlético Junio|
|21 Jul 21||Atletico PR ||4 - 1|| ||América de Cal|
|21 Jul 21||Arsenal Sarandi ||1 - 1|| ||Sporting Crista|
|20 Jul 21||Gremio ||1 - 2|| ||LDU Quito|
|16 Jul 21||Nacional Montev ||1 - 2|| ||Peñarol|
|16 Jul 21||Deportivo Tách ||2 - 2|| ||Rosario Central|
The CONMEBOL Sudamericana, named as Copa Sudamericana is an annual international club football competition organized by CONMEBOL since 2002. It is the second-most prestigious club competition in South American football. CONCACAF clubs were invited between 2004 and 2008. The CONMEBOL Sudamericana began in 2002, replacing the separate competitions Copa Merconorte and Copa Mercosur (that had replaced Copa CONMEBOL) by a single competition. Since its introduction, the competition has been a pure elimination tournament with the number of rounds and teams varying from year to year.
The CONMEBOL Sudamericana is considered a merger of defunct tournaments such as the Copa CONMEBOL, Copa Mercosur and Copa Merconorte. The winner of the Copa Sudamericana becomes eligible to play in the Recopa Sudamericana. They gain entry onto the next edition of the Copa Libertadores, South America's premier club competition, and also contest the J.League Cup / Copa Sudamericana Championship.
The reigning champion of the competition is Ecuadorian club Independiente del Valle, who defeated Argentine club Colón in the most recent final.
Argentine clubs have accumulated the most victories with eight while containing the largest number of different winning teams, with a total of six clubs having won the title. The cup has been won by 15 different clubs. Argentine clubs Boca Juniors and Independiente are the most successful clubs in the cup's history, having won the tournament twice, with Boca Juniors being the only one to achieve it back-to-back, in 2004 and 2005.
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