Issam Ben Khémis (born 10 January 1996) is a French-born Tunisian footballer who plays as a midfielder for Tunisia Stade Tunisien.
On 14 May 2016, Ben Khémis made his Ligue 1 debut against Gazélec Ajaccio.
On 15 July 2017, he featured as a trialist for English League One club Doncaster Rovers in their pre-season friendly against Tadcaster Albion, and on 3 August signed for the club on a two-year deal.