Powell-Pepper was born into a family with an Aboriginal and Torres Strait Islander mother and an English father. He initially attended Mount Lawley Senior High School before switching to Wesley College on a scholarship.
In 2016, Powell-Pepper made his senior debut for the East Perth Football Club during round 20 of the 2016 WAFL season going on to play all the remaining games for the year.
Powell-Pepper was drafted by the Port Adelaide Football Club with their second selection and eighteenth overall in the 2016 national draft. He made his AFL debut in Port Adelaide's twenty-eight point win against Sydney in the opening round of the 2017 season at the Sydney Cricket Ground. He was named that round's AFL Rising Star nominee after kicking two goals in the match, the first with his first kick in AFL football. In a game against Melbourne, he recorded 17 tackles, beating the club's previous record which was 16.
Former Youth Teams
Former Senior Teams
Former Club Staff