James Alexander Knox (born 4 November 1995) is a British road racing cyclist, who currently rides for UCI WorldTeam Deceuninck–Quick-Step.
In 2017, Knox came second in the under-23 version of Liège–Bastogne–Liège. In September of that year Quick-Step Floors announced that Knox would turn professional with the team for the 2018 season.
In May 2019, he was named in the startlist for the 2019 Giro d'Italia. In August 2019, he was named in the startlist for the 2019 Vuelta a España. He was in the general classification Top 10 with two stages to go, however he lost 11 minutes on the penultimate stage after crashing the day before, eventually finishing in 11th place.