Isaiah Simmons (born July 26, 1998) is an American football inside linebacker for the Arizona Cardinals of the National Football League (NFL). He played college football at Clemson and was drafted by the Cardinals eighth overall in the 2020 NFL Draft. While at Clemson, Simmons was noted for his positional versatility as he played linebacker, defensive end, cornerback, and safety.
Simmons was traded to the New York Giants on August 24, 2023, in exchange for a seventh-round pick (No.226) in the 2024 NFL draft.
On April 5, 2024 the Giants re-signed Simmons to a 1 year, $2,000,000 deal.