Isaac Yiadom (born February 20, 1996) is an American professional football cornerback for the San Francisco 49ers of the National Football League (NFL). A graduate of Doherty Memorial High School in Worcester, Massachusetts, he played college football at Boston College.
The Denver Broncos selected Yiadom in the third round (99th overall) of the 2018 NFL draft.
On March 18, 2024, Yiadom signed a one–year contract with the San Francisco 49ers.