15 Jan 22 | r18 | Asteras Trip | 1 - 0 | NFC Volos |
15 Jan 22 | r18 | Lamia | 2 - 1 | Ionikos |
15 Jan 22 | r18 | Apollon Smir | 0 - 0 | Aris |
15 Jan 22 | r18 | PAOK | 3 - 0 | OFI |
16 Jan 22 | r18 | AEK | 1 - 2 | Panetolikos |
16 Jan 22 | r18 | Giannina | 1 - 1 | Atromitos |
16 Jan 22 | r18 | Panathinaiko | 0 - 0 | Olympiakos |