19 Nov 21 | r15 | Chornomorets | 1 - 6 | Dynamo Kiev |
20 Nov 21 | r15 | FC Lviv | 2 - 1 | Zorya |
20 Nov 21 | r15 | Shakhtar Don | 2 - 0 | Rukh Lviv |
20 Nov 21 | r15 | SC Dnipro-1 | 3 - 1 | FC Olexandri |
21 Nov 21 | r15 | Mynai | 2 - 2 | Inhulets |
21 Nov 21 | r15 | Vorskla | 5 - 1 | Mariupol |
21 Nov 21 | r15 | Desna | 0 - 1 | FC Kolos Kov |
22 Nov 21 | r15 | Veres Rivne | 2 - 0 | FC Metalist |