12 Nov 21 | r15 | TOP Oss | 0 - 0 | Helmond Spor |
13 Nov 21 | r15 | FC Eindhoven | 5 - 1 | FC Dordrecht |
14 Nov 21 | r15 | De Graafscha | 1 - 1 | SC Telstar |
14 Nov 21 | r15 | ADO Den Haag | 2 - 0 | VVV-Venlo |
14 Nov 21 | r15 | Excelsior | 4 - 4 | Almere City |
22 Nov 21 | r15 | Jong Ajax | 2 - 1 | Roda JC |
22 Nov 21 | r15 | Jong AZ | 0 - 0 | FC Emmen |
22 Nov 21 | r15 | Jong PSV | 0 - 0 | NAC Breda |
22 Nov 21 | r15 | Jong Utrecht | 0 - 1 | FC Volendam |