03 Dec 21 | r18 | Almere City | 2 - 0 | FC Eindhoven |
03 Dec 21 | r18 | FC Den Bosch | 0 - 5 | NAC Breda |
03 Dec 21 | r18 | FC Dordrecht | 2 - 5 | Roda JC |
03 Dec 21 | r18 | Helmond Spor | 1 - 1 | FC Volendam |
03 Dec 21 | r18 | MVV Maastric | 1 - 1 | TOP Oss |
03 Dec 21 | r18 | SC Telstar | 1 - 3 | VVV-Venlo |
06 Dec 21 | r18 | Jong Ajax | 1 - 0 | FC Emmen |
06 Dec 21 | r18 | Jong AZ | 0 - 2 | Excelsior |
06 Dec 21 | r18 | Jong PSV | 2 - 3 | De Graafscha |
06 Dec 21 | r18 | Jong Utrecht | 1 - 4 | ADO Den Haag |