25 Feb 22 | r28 | Almere City | 0 - 1 | VVV-Venlo |
25 Feb 22 | r28 | Jong AZ | 1 - 3 | FC Eindhoven |
25 Feb 22 | r28 | FC Dordrecht | 3 - 1 | MVV Maastric |
25 Feb 22 | r28 | FC Emmen | 2 - 1 | Jong Ajax |
25 Feb 22 | r28 | Excelsior | 2 - 0 | Roda JC |
25 Feb 22 | r28 | De Graafscha | 0 - 0 | FC Den Bosch |
25 Feb 22 | r28 | NAC Breda | 3 - 1 | Jong PSV |
25 Feb 22 | r28 | TOP Oss | 4 - 1 | Jong Utrecht |
25 Feb 22 | r28 | FC Volendam | 4 - 1 | Helmond Spor |
21 Mar 22 | r28 | ADO Den Haag | 2 - 1 | SC Telstar |