04 May 21 | r03 | Bahia | 2 - 2 | Independient |
04 May 21 | r03 | Metropolitan | 3 - 2 | SD Aucas |
05 May 21 | r03 | FBC Melgar | 1 - 0 | Atletico PR |
05 May 21 | r03 | Palestino | 0 - 1 | Newells Old |
05 May 21 | r03 | Huachipato | 1 - 1 | Rosario Cent |
05 May 21 | r03 | Montevideo C | 4 - 0 | Club Deporti |
05 May 21 | r03 | Bolivar | 0 - 0 | Ceara |
06 May 21 | r03 | Bragantino | 0 - 1 | Talleres de |
06 May 21 | r03 | Arsenal Sara | 3 - 0 | Wilstermann |
06 May 21 | r03 | Club Liberta | 1 - 2 | Atletico GO |
06 May 21 | r03 | Gremio | 8 - 0 | Aragua F.C. |
07 May 21 | r03 | San Lorenzo | 1 - 1 | 12 de Octubr |
07 May 21 | r03 | Sport Huanca | 0 - 3 | Corinthians |
07 May 21 | r03 | Peñarol | 3 - 0 | Club River P |
07 May 21 | r03 | La Equidad | 0 - 1 | Lanus |
08 May 21 | r03 | Deportes Tol | 1 - 1 | Emelec |