11 May 21 | r04 | Metropolitan | 0 - 1 | Atletico PR |
11 May 21 | r04 | Bragantino | 2 - 0 | Emelec |
12 May 21 | r04 | Montevideo C | 1 - 1 | Independient |
12 May 21 | r04 | Talleres de | 0 - 0 | Deportes Tol |
12 May 21 | r04 | 12 de Octubr | 1 - 2 | Huachipato |
12 May 21 | r04 | Ceara | 0 - 0 | Arsenal Sara |
13 May 21 | r04 | San Lorenzo | 1 - 2 | Rosario Cent |
13 May 21 | r04 | Bolivar | 2 - 2 | Wilstermann |
13 May 21 | r04 | Atletico GO | 0 - 0 | Palestino |
13 May 21 | r04 | Club Deporti | 0 - 1 | Bahia |
13 May 21 | r04 | Aragua F.C. | 1 - 2 | La Equidad |
13 May 21 | r04 | Gremio | 3 - 1 | Lanus |
14 May 21 | r04 | SD Aucas | 2 - 1 | FBC Melgar |
14 May 21 | r04 | Club River P | 2 - 1 | Sport Huanca |
14 May 21 | r04 | Peñarol | 4 - 0 | Corinthians |
14 May 21 | r04 | Club Liberta | 1 - 0 | Newells Old |