24 May 22 | r06 | Santos FC | 1 - 1 | Banfield |
24 May 22 | r06 | Unión La Ca | 3 - 2 | Universidad |
25 May 22 | r06 | Internaciona | 5 - 1 | 9 de Octubre |
25 May 22 | r06 | Independient | 1 - 1 | Guaireña FC |
25 May 22 | r06 | LDU Quito | 1 - 1 | Atletico GO |
25 May 22 | r06 | Defensa y Ju | 0 - 2 | Deportes Ant |
25 May 22 | r06 | Lanus | 1 - 0 | Metropolitan |
25 May 22 | r06 | Wanderers | 0 - 0 | Barcelona SC |
25 May 22 | r06 | Sao Paulo | 1 - 0 | Ayacucho FC |
25 May 22 | r06 | Wilstermann | 0 - 2 | Everton de V |
26 May 22 | r06 | Independient | 0 - 2 | Ceara |
26 May 22 | r06 | Real Esppor | 0 - 1 | General Caba |
26 May 22 | r06 | Racing Club | 0 - 1 | CA River Pla |
26 May 22 | r06 | FBC Melgar | 3 - 1 | Cuiaba |
27 May 22 | r06 | Atlético Ju | 0 - 4 | Union |
27 May 22 | r06 | Oriente Petr | 1 - 10 | Fluminense |