22 Dec 21 | r16 | Pineto | 0 - 1 | US Tolentino |
22 Dec 21 | r16 | U.S.D. Recan | 3 - 0 | San Nicolò |
22 Dec 21 | r16 | Trastevere | 3 - 2 | S.S. Chieti |
22 Dec 21 | r16 | Polisportiva | 1 - 0 | Alma Juventu |
22 Dec 21 | r16 | A.S.D. Atlet | 1 - 0 | Matese |
22 Dec 21 | r16 | Montegiorgio | 1 - 2 | Castelnuovo |
22 Dec 21 | r16 | Nereto | 1 - 0 | Castelfidard |
22 Dec 21 | r16 | Porto D Asco | 1 - 2 | Vastese Calc |
22 Dec 21 | r16 | Aurora Alto | 2 - 3 | Sambenedette |