12 Mar 21 | r16 | Smouha SC | 5 - 0 | Aswan SC |
13 Mar 21 | r16 | ENPPI | 1 - 1 | Al-Masry |
14 Mar 21 | r16 | Al-Mokawloon | 0 - 1 | Ghazl El Mah |
15 Mar 21 | r16 | National Ban | 0 - 1 | Al-Ittihad |
16 Mar 21 | r16 | Ceramica Cle | 1 - 2 | Wadi Degla |
16 Mar 21 | r16 | Tala-'ea El | 1 - 1 | Ismaily |
14 Apr 21 | r16 | Pyramids FC | 1 - 1 | Misr Lel Mak |
22 Apr 21 | r16 | El Entag El | 0 - 2 | Zamalek SC |
30 Apr 21 | r16 | Al Ahly SC | 1 - 1 | El Gouna FC |