24 Aug 21 | r25 | Resistencia | 3 - 0 | Fulgencio Ye |
25 Aug 21 | r25 | 2 de Mayo | 1 - 3 | Sportivo Ame |
25 Aug 21 | r25 | Independient | 0 - 1 | General Caba |
25 Aug 21 | r25 | General Día | 0 - 1 | Sportivo Ite |
25 Aug 21 | r25 | Club Sportiv | 2 - 0 | Rubio Ñu |
26 Aug 21 | r25 | Deportivo Ca | 2 - 2 | Atyrá |
26 Aug 21 | r25 | Fernando de | 1 - 0 | 3 de Febrero |
26 Aug 21 | r25 | Guaraní de | 0 - 0 | Deportivo Sa |
01 Sep 21 | r25 | Sportivo Tri | 2 - 2 | Tacuary |