24 Sep 21 | r30 | Sportivo Tri | 1 - 0 | Resistencia |
24 Sep 21 | r30 | 3 de Febrero | 1 - 1 | Guaraní de |
25 Sep 21 | r30 | Sportivo Ame | 3 - 0 | Club Sportiv |
25 Sep 21 | r30 | Atyrá | 2 - 1 | Independient |
26 Sep 21 | r30 | Sportivo Ite | 3 - 0 | Deportivo Ca |
26 Sep 21 | r30 | Fulgencio Ye | 2 - 1 | Deportivo Sa |
26 Sep 21 | r30 | 2 de Mayo | 0 - 0 | Fernando de |
27 Sep 21 | r30 | Tacuary | 1 - 0 | General Día |
27 Sep 21 | r30 | General Caba | 4 - 1 | Rubio Ñu |