12 Feb 22 | r16 | NK Varaždin | 2 - 1 | Orijent 1919 |
12 Feb 22 | r16 | Rudeš | 4 - 1 | Dubrava |
12 Feb 22 | r16 | Opatija | 2 - 1 | Cibalia |
12 Feb 22 | r16 | Solin | 2 - 1 | Kustošija |
12 Feb 22 | r16 | Osijek II | 0 - 3 | Sesvete |
12 Feb 22 | r16 | Jarun | 1 - 1 | Dugopolje |
13 Feb 22 | r16 | Croatia Zmij | 2 - 0 | NK Inter Zap |
13 Feb 22 | r16 | Dinamo Zagre | 2 - 0 | BSK Bijelo B |