12 Mar 22 | Quarter-Final | Leganés II | 2 - 3 | Arenteiro |
12 Mar 22 | Quarter-Final | Compostela | 0 - 1 | UD Llanera |
12 Mar 22 | Quarter-Final | Ceares | 0 - 1 | Unión Adarv |
12 Mar 22 | Quarter-Final | Pontevedra | 3 - 0 | Gimnástica |
13 Mar 22 | Quarter-Final | CD Móstoles | 2 - 1 | Marino |
13 Mar 22 | Quarter-Final | Salamanca UD | 0 - 3 | Coruxo |
13 Mar 22 | Quarter-Final | Langreo | 0 - 0 | Navalcarnero |
13 Mar 22 | Quarter-Final | Cristo Atlé | 3 - 5 | Bergantiños |
13 Mar 22 | Quarter-Final | Arosa | 0 - 0 | Real Avilés |