11 Dec 21 | r16 | Linares Depo | 0 - 0 | Linense |
11 Dec 21 | r16 | Sevilla Atle | 1 - 1 | Real Madrid |
11 Dec 21 | r16 | Castellón | 1 - 3 | FC Andorra |
11 Dec 21 | r16 | Alcoyano | 0 - 1 | Llagostera |
11 Dec 21 | r16 | Algeciras CF | 3 - 0 | San Fernando |
12 Dec 21 | r16 | Barcelona B | 3 - 1 | Atlético Ba |
12 Dec 21 | r16 | Gimnastic | 1 - 0 | Villarreal B |
12 Dec 21 | r16 | Atlético Sa | 4 - 0 | Cornellà |
12 Dec 21 | r16 | UCAM Murcia | 1 - 2 | Albacete |
02 Feb 22 | r16 | Sabadell | 0 - 0 | Betis Deport |