20 Nov 21 | r16 | Bideford | 1 - 2 | Winchester C |
20 Nov 21 | r16 | Bristol Mano | 1 - 0 | Cirencester |
20 Nov 21 | r16 | Highworth To | 1 - 0 | Frome Town |
20 Nov 21 | r16 | Lymington To | 3 - 2 | Barnstaple T |
20 Nov 21 | r16 | Melksham Tow | 4 - 2 | Willand Rove |
20 Nov 21 | r16 | Paulton Rove | 3 - 0 | Cinderford T |
20 Nov 21 | r16 | Plymouth Par | 1 - 0 | AFC Totton |
20 Nov 21 | r16 | Sholing | 4 - 1 | Mangotsfield |
20 Nov 21 | r16 | Slimbridge | 2 - 3 | Larkhall Ath |