25 Feb 22 | r16 | Royal FC Bob | 1 - 1 | ASEC Koudoug |
25 Feb 22 | r16 | Majestic | 0 - 3 | AS Koupela |
25 Feb 22 | r16 | SONABEL | 1 - 0 | Salitas FC |
26 Feb 22 | r16 | RC Bobo-Diou | 0 - 1 | ASF Bobo Dio |
26 Feb 22 | r16 | AS Douanes | 1 - 0 | Vitesse Burk |
26 Feb 22 | r16 | Kiko | 0 - 0 | Etoile Filan |
26 Feb 22 | r16 | Rail Club du | 0 - 1 | ASFA-Yenneng |