18 Sep 21 | r02 | CSM Bucureș | 27 - 30 | Rostov-Don W |
18 Sep 21 | r02 | Ferencváros | 33 - 27 | RK Podravka |
18 Sep 21 | r02 | Odense Hånd | 21 - 27 | Metz Handbal |
18 Sep 21 | r02 | Brest Bretag | 26 - 23 | Team Esbjerg |
18 Sep 21 | r02 | RK Krim Wome | 26 - 31 | Győri Audi |
18 Sep 21 | r02 | Vipers Krist | 34 - 25 | IK Sävehof |
19 Sep 21 | r02 | HBC CSKA Mos | 34 - 27 | Kastamonu Bl |
19 Sep 21 | r02 | ŽRK Budućn | 29 - 34 | Borussia Dor |