16 Oct 21 | r04 | Ferencváros | 31 - 31 | Team Esbjerg |
16 Oct 21 | r04 | Brest Bretag | 35 - 22 | RK Podravka |
16 Oct 21 | r04 | Vipers Krist | 39 - 25 | Kastamonu Bl |
17 Oct 21 | r04 | HBC CSKA Mos | 29 - 28 | IK Sävehof |
17 Oct 21 | r04 | ŽRK Budućn | 19 - 25 | Rostov-Don W |
17 Oct 21 | r04 | Borussia Dor | 22 - 25 | CSM Bucureș |
17 Oct 21 | r04 | RK Krim Wome | 28 - 29 | Metz Handbal |
17 Oct 21 | r04 | Odense Hånd | 26 - 31 | Győri Audi |