13 Nov 21 | r07 | Ferencváros | 31 - 30 | CSM Bucureș |
13 Nov 21 | r07 | Brest Bretag | 25 - 21 | ŽRK Budućn |
13 Nov 21 | r07 | Győri Audi | 37 - 20 | Kastamonu Bl |
13 Nov 21 | r07 | RK Podravka | 22 - 23 | Rostov-Don W |
14 Nov 21 | r07 | Borussia Dor | 29 - 32 | Team Esbjerg |
14 Nov 21 | r07 | HBC CSKA Mos | 21 - 21 | RK Krim Wome |
14 Nov 21 | r07 | Odense Hånd | 27 - 32 | Vipers Krist |
14 Nov 21 | r07 | IK Sävehof | 28 - 31 | Metz Handbal |