|25 Jan 22||Tennessee-Martin ||-|| Southern Illinois-Edwardsville|
|28 Jan 22||Southern Illinois-Edwardsville ||-|| Tennessee State|
|29 Jan 22||Southeast Missouri ||-|| Southern Illinois-Edwardsville|
|01 Feb 22||Austin Peay ||-|| Southern Illinois-Edwardsville|
|04 Feb 22||Southern Illinois-Edwardsville ||-|| Eastern Illinois|
|22 Jan 22||Morehead State|| ||-|| ||Southern Illinois-Edwardsville|
|21 Jan 22||Tennessee Tech|| ||94 - 76|| ||Southern Illinois-Edwardsville|
|18 Jan 22||Southern Illinois-Edwardsville|| ||64 - 80|| ||Belmont|
|15 Jan 22||Southern Illinois-Edwardsville|| ||P - P|| ||Southeast Missouri|
|14 Jan 22||Eastern Illinois|| ||53 - 66|| ||Southern Illinois-Edwardsville|
The SIU Edwardsville Cougars men's basketball team represents Southern Illinois University Edwardsville (SIUE) in the Ohio Valley Conference of NCAA Division I basketball. The Cougars play their home matches at the Sam M. Vadalabene Center located in the SIUE core campus in Edwardsville, Illinois.
The SIUE basketball program first entered competition on November 23, 1967 under the leadership of Naismith Memorial Basketball Hall of Fame coach Harry Gallatin. The newborn program had no scholarships, inadequate facilities, and very little money to work with. Home games were played at the Shurtleff College gymnasium in Alton, usually with crowds of fewer than a dozen fans in attendance. Gallatin departed as the program's coach after three years (while remaining as athletic director and golf coach for many years) with a record of 19–31.