18 May 21 | r05 | Independient | 1 - 0 | Bahia |
18 May 21 | r05 | Club River P | 2 - 1 | Peñarol |
19 May 21 | r05 | Talleres de | 0 - 1 | Bragantino |
19 May 21 | r05 | Wilstermann | 1 - 2 | Arsenal Sara |
19 May 21 | r05 | Atletico GO | 0 - 0 | Club Liberta |
19 May 21 | r05 | Emelec | 2 - 0 | Deportes Tol |
20 May 21 | r05 | Rosario Cent | 5 - 0 | Huachipato |
20 May 21 | r05 | Atletico PR | 1 - 0 | FBC Melgar |
20 May 21 | r05 | SD Aucas | 3 - 0 | Metropolitan |
20 May 21 | r05 | 12 de Octubr | 0 - 2 | San Lorenzo |
20 May 21 | r05 | Ceara | 2 - 0 | Bolivar |
20 May 21 | r05 | Newells Old | 3 - 1 | Palestino |
21 May 21 | r05 | Club Deporti | 0 - 4 | Montevideo C |
21 May 21 | r05 | Corinthians | 5 - 0 | Sport Huanca |
21 May 21 | r05 | Lanus | 4 - 1 | La Equidad |
21 May 21 | r05 | Aragua F.C. | 2 - 6 | Gremio |