25 May 21 | r06 | Palestino | 1 - 2 | Club Liberta |
25 May 21 | r06 | Newells Old | 1 - 1 | Atletico GO |
26 May 21 | r06 | Emelec | 1 - 4 | Talleres de |
26 May 21 | r06 | Deportes Tol | 1 - 2 | Bragantino |
26 May 21 | r06 | Independient | 1 - 0 | Club Deporti |
26 May 21 | r06 | Bahia | 2 - 4 | Montevideo C |
27 May 21 | r06 | Rosario Cent | 0 - 0 | 12 de Octubr |
27 May 21 | r06 | Huachipato | 0 - 3 | San Lorenzo |
27 May 21 | r06 | Corinthians | 4 - 0 | Club River P |
27 May 21 | r06 | Sport Huanca | 0 - 0 | Peñarol |
27 May 21 | r06 | Wilstermann | 1 - 0 | Ceara |
27 May 21 | r06 | Arsenal Sara | 3 - 1 | Bolivar |
28 May 21 | r06 | Atletico PR | 4 - 0 | SD Aucas |
28 May 21 | r06 | FBC Melgar | 0 - 0 | Metropolitan |
28 May 21 | r06 | Lanus | 0 - 0 | Aragua F.C. |
28 May 21 | r06 | La Equidad | 0 - 0 | Gremio |