17 May 22 | r05 | Banfield | 1 - 1 | Universidad |
17 May 22 | r05 | Internaciona | 2 - 0 | Independient |
17 May 22 | r05 | Ceara | 6 - 0 | General Caba |
18 May 22 | r05 | 9 de Octubre | 2 - 3 | Guaireña FC |
18 May 22 | r05 | Atletico GO | 1 - 0 | Deportes Ant |
18 May 22 | r05 | Atlético Ju | 2 - 0 | Oriente Petr |
18 May 22 | r05 | CA River Pla | 1 - 2 | Cuiaba |
18 May 22 | r05 | Ayacucho FC | 0 - 2 | Everton de V |
19 May 22 | r05 | Racing Club | 1 - 0 | FBC Melgar |
19 May 22 | r05 | Santos FC | 1 - 0 | Unión La Ca |
19 May 22 | r05 | LDU Quito | 2 - 2 | Defensa y Ju |
19 May 22 | r05 | Independient | 4 - 0 | Real Esppor |
19 May 22 | r05 | Union | 0 - 0 | Fluminense |
20 May 22 | r05 | Lanus | 1 - 2 | Wanderers |
20 May 22 | r05 | Metropolitan | 2 - 2 | Barcelona SC |
20 May 22 | r05 | Sao Paulo | 3 - 0 | Wilstermann |