05 Feb 22 | r12 | Brest Bretag | 31 - 25 | Borussia Dor |
05 Feb 22 | r12 | Ferencváros | 25 - 25 | Rostov-Don W |
05 Feb 22 | r12 | RK Krim Wome | 36 - 28 | Kastamonu Bl |
05 Feb 22 | r12 | ŽRK Budućn | 25 - 36 | Team Esbjerg |
05 Feb 22 | r12 | Vipers Krist | 25 - 31 | Metz Handbal |
06 Feb 22 | r12 | HBC CSKA Mos | 23 - 27 | Győri Audi |
06 Feb 22 | r12 | CSM Bucureș | 29 - 21 | RK Podravka |
06 Feb 22 | r12 | Odense Hånd | 37 - 24 | IK Sävehof |